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doi: 10.1039/D1RA06266B

In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings

For vitamin B12 pills, most people take these daily in doses recommended by their doc but taking 1,000 mcg daily is pretty standard

About 15 percent of adults above 65 years have subclinical deficiency, probably contributed to by the use of H2-receptor blockers for hyperacidity treatment, since these also reduce cobalamine levels